Spermidine in dementia
نویسندگان
چکیده
منابع مشابه
Spermidine for a Long, Dementia-Free Life?
Spermidine, N-(3-aminopropyl) butane-1,4-diamine, is a low-molecular-mass organic base (C7H19N3, CAS 124-20-9) and belongs to the polyamine family which includes spermine and putrescine, the direct precursor of spermidine (Figure 1). At ambient temperature (22-25 °C) spermidine is a colorless liquid or a white powder. In biological samples, the two primary amine groups and the secondary amine g...
متن کاملRegulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine.
Polyamine biosynthesis in intact cells can be exquisitely controlled with exogenous polyamines through the regulation of rate-limiting biosynthetic enzymes, particularly ornithine decarboxylase (ODC). In an attempt to exploit this phenomenon as an antiproliferative strategy, certain polyamine analogues have been identified [Porter, Cavanaugh, Stolowich, Ganis, Kelly & Bergeron (1985) Cancer Res...
متن کاملSpermidine Biosynthesis in Saccharomyces cereuisiae
We have cloned and sequenced the Saccharomyces cerevisiae gene for S-adenosylmethionine decarboxylase. This enzyme contains covalently bound pyruvate which is essential for enzymatic activity. We have shown that this enzyme is synthesized as a M, 46,000 proenzyme which is then cleaved post-translationally to form two polypeptide chains: a fi subunit (Mr 10,000) from the amino-terminal portion a...
متن کاملSpermine and Spermidine
1Plant Breeding Institute, ARC, SF-31600 Jokioinen, Finland; 2Department of Genetics, SF-00014 University of Helsinki, Helsinki, Finland In a recent article describing the effects of various reaction conditions, Blanchard et al. ~1~ ment ioned that spermine and spermidine at concentrations between 0.5 and 3 mM had no effect on PCR amplification ~2'3> with their sequence-specific primers. Becaus...
متن کاملEnzymatic assay for spermidine.
The polyamine spermidine (NH,(CH&NH(CH&NH,) is widespread in nature. It is present in mammalian tissues (1, 2), plants (3), bacteria (47), ribosomes (6, 8), and bacteriophages (9-11). There are various methods for its identification, including steam distillation (12)) paper chromatography (13-18)) paper electrophoresis (14, 16, 17, 19), ion exchange chromatography (2, 5), gas chromatography (31...
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ژورنال
عنوان ژورنال: Wiener klinische Wochenschrift
سال: 2019
ISSN: 0043-5325,1613-7671
DOI: 10.1007/s00508-019-01588-7